Publications

Google Scholar profile

Full text Harms MJ & Thornton JW. “Historical contingency and its biophysical basis in glucocorticoid receptor evolution.” (2014). Nature. doi:10.1038/nature13410
Full text Harms MJ & Thornton JW. “Evolutionary biochemistry: Revealing the historical and physical causes of protein function.” (2013). Nature Reviews Genetics. 14(8):559-571
Full text Harms MJ, Eick GN, Goswami D, Colucci JK, Griffin PR, Ortlund EA, Thornton JW. “Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors.” (2013) Proceedings of the National Academy of Sciences, USA.  110(28):11475–11480
Full text Williams SG, Harms MJ, Hall KB. “Resurrection of an Urbilaterian U1A/U2B”/SNF protein.” (2013) Journal of Molecular Biology.  425(20):3846–3862 
Full text Eick GN, Colucci J, Harms MJ, Ortlund EA, Thornton JW. “Evolution of minimal specificity in the steroid receptors.” (2012) PLoS Genetics. 8(11):e1003072 
Full text Harms MJ, Schlessman JL, Sue GR, García-Moreno E. B. “Arginine is ionized at internal positions in a protein.” (2011) Proceedings of the National Academy of Sciences, USA. 108(47):18954-9. Listed as “Must Read” on Faculty of 1000.
Full text Bridgham JT, Eick G, Larroux C, Deshpande K, Harms MJ, Gauthier MEA, Ortlund EA, Degnan BM, Thornton JW (2010). “Protein evolution by molecular tinkering: diversification of the nuclear receptor superfamily from a ligand-dependent ancestor.” PLoS Biology 8(10): e1000497 
Full text Harms MJ, Thornton JW. (2010). “Analyzing protein structure and function using ancestral gene reconstruction.” Current Opinions in Structural Biology. 20(3):360-366.
Full text Harms MJ, Castañeda CA, Schlessman JL, Sue GR, Isom DG, Cannon BR, García- Moreno E. B. (2009). “The pKa values of acidic and basic residues buried at the same internal location in a protein are governed by different factors.” Journal of Molecular Biology. 389:34-47. Listed as “Must Read” on Faculty of 1000.
Full text Thesis.  Harms, MJ. “Molecular determinants of pKa values of internal ionizable groups in staphylococcal nuclease.” The Johns Hopkins University, ProQuest, UMI Dissertations Publishing, 2009. 3339887.
Full text Harms MJ, Schlessman JL, Chimenti MS, Sue GR, Damjanovic A, García-Moreno E. B. (2008). “A buried lysine that titrates with a normal pKa: Role of conformational flexibility at the protein–water interface as a determinant of pKa values.” Protein Science. 17:833-845.
Full text Hays FA, Teegarden A, Jones ZJR, Harms MJ, Raup D, Watson F, Cavaliere E, Ho PS. (2005). “How sequence defines structure: a crystallographic map of DNA structure and conformation.” Proceedings of the National Academy of Sciences USA. 102(20):7157-7162.
Full text Harms MJ, Wilmarth PA, Kapfer DM, Steel EA, David LL, Bachinger HP, Lampi KJ. (2003). “Laser light-scattering evidence for an altered association of βB1- crystallin deamidated in the connecting peptide.” Protein Science. 13:678-686.